Exon level expression profile of MCF7 cells with p53 splice variant knocked out 4hr post 20gy irradiation

In order to explore the funciton of p53 splice variant in DNA damage response, we utilized CRISPR-cas9 genome editing technique to specifically knock out this variant in MCF7 cells.

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Chen J, Crutchley J, Zhang D, Owzar K, Kastan MB