Social defeat effect on mice prefrontal cortex

Behavioral analysis confirmed that the 14-day social defeat sessions resulted in induction of depressive-like states measured in social interaction and light/dark tests. The combined data show that stress-induced depressive states are associated with molecular and structural changes that demyelinate the prefrontal cortex.

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Lehmann ML, Weigel TK, Elkahloun AG, Herkenham M