TGFbeta-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells

GSE84500

Homo sapiens

48 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

Gene Expression analysis of a differentiation timeseries of human Mesenchymal Stem Cells (hMSCs) in the presence of adipogenic/osteogenic factors. hMSCs differentiate into fat cells when treated with dexamethasone (10^-6 M), insulin (10 ug/ml), rosiglitazone (10^-7 M) and IBMX (250 uM). TGFbeta (5 ng/ml) inhibits this process and redirects these cells to differentiate into bone cells.

PubMed ID

27562730

Publication Title

TGFβ-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation.

Total Samples

Submitter’s Institution

Radboud University Nijmegen

Authors

van Zoelen EJ, Duarte I, Hendriks JM, van der Woning SP

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-84500

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