Expression data from Congenital disorders of Glycosylation type-1 patients (CDG-I)

Disruption of N-linked glycosylation has a broad impact on proper glycosylation of nascent glycoproteins in the endoplasmic reticulum, which affect multiple signalling pathways( by changing the stability of membrane proteins or the signalling ability of membrane receptors) and may be responsible of the fibrotic stage associated to CDG type-I.

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Lecca MR, Maag C, Berger EG, Hennet T