Gene expression profiling reveals novel protective effects of Aminaphtone on ECV304 endothelial cells

Aminaphtone, a drug used in the treatment of chronic venous insufficiency (CVI), showed a remarkable role in the modulation of several vasoactive factors, like endothelin-1 and adhesion molecules. We analysed in vitro the effects of Aminaphtone on whole-genome gene expression. ECV304 endothelial cells were stimulated with IL-1 100 U/ml in the presence or absence of Aminaphtone 6 g/ml. Gene expression profiles were compared at 1, 3, and 6 h after stimulation by microarray.

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Salazar G, Bellocchi C, Todoerti K, Saporiti F, Piacentini L, Scorza R, Colombo GI