Gene expression analysis in the aorta from non-diabetic or STZ-induced diabetic apolipoprotein E deficient (ApoE-/-) mice fed with high fat diet in the presence or absence of PKC inhibitor, ruboxistaurin (RBX, or LY333531)

GSE79623

Mus musculus

16 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

We found that hyperglycemia and elevated fatty acids in diabetes could activate protein kinase C- isoforms and selectively induce insulin resistance via inhibiting vascular insulin signaling.

PubMed ID

27200419

Publication Title

Insulin decreases atherosclerosis by inducing endothelin receptor B expression.

Total Samples

Submitter’s Institution

Joslin Diabetes Center

Authors

Park K, Mima A, Li Q, Rask-Madsen C, He P, Mizutani K, Katagiri S, Maeda Y, Wu IH, Khamaisi M, Preil SR, Maddaloni E, Sørensen D, Rasmussen LM, Huang PL, King GL

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-79623

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