Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis of 405 tumors by BMI

Background: Obesity is a risk factor for breast cancer in postmenopausal women and is associated with decreased survival and less favorable clinical characteristics such as greater tumor burden, higher grade, and poor prognosis, regardless of menopausal status. Despite the negative impact of obesity on clinical outcome, molecular mechanisms through which excess adiposity influences breast cancer etiology are not well-defined.

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Toro AL, Costantino NS, Shriver CD, Ellsworth DL, Ellsworth RE