Comparative expression analysis of carfilzomib-resistant and parental LP-1 human multiple myeloma cells

GSE78069

Homo sapiens

6 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

LP-1 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell culture, denoted LP-1/Cfz, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.

PubMed ID

27626179

Publication Title

Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.

Total Samples

Submitter’s Institution

George Washington University

Authors

Riz I, Hawley TS, Marsal JW, Hawley RG

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-78069

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