Expression data from human 3D skin models in response to IL-31 treatment

Atopic dermatitis, a chronic inflammatory skin disease with increasing prevalance, is closely associated with skin barrier defects. A cytokine related to disease severity and inhibition of keratinocyte differentiation is IL-31. To identify its molecular targets, IL-31-dependent gene expression was determined in 3-dimensional organotypic skin models.

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Hänel KH, Pfaff CM, Cornelissen C, Amann PM, Marquardt Y, Czaja K, Kim A, Lüscher B, Baron JM