Expression data from TGRL lipolysis products treated normal human astrocytes

Lipotoxicity is a metabolic disorder that results from accumulation of lipids, particularly fatty acids, in non-adipose tissue leading to cellular dysfunction, lipid droplet formation, activate the ATF3 stress pathway, induce secretion of inflammatory cytokines, and increase APP. Our observations are consistent with neurovascular lipotoxicity that could play a role in cognitive decline with aging.

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Lee LL, Aung HH, Wilson DW, Anderson SE, Rutledge JC, Rutkowsky JM