Effect of iBET762+ on transcriptome of 20861 and 20863 W12 cells

GSE75987

Homo sapiens

12 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

To determine the effect of iBET762+, a bromodomain BET inhibitor, on the transcription of 20861 and 20863 cells. These cells are subclones of W12 cells, derived from cervical intraepithelial neoplastic lesion. 20861 contains integrated HPV16 DNA and 20863 contains extrachromosomal HPV16 DNA. iBET762+ decreases expression of the HPV16 E6 and E7 oncogenes in both cell lines and this is expected to have dramatic effects on the cellular transcriptome

PubMed ID

27624132

Publication Title

Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral Oncogenes.

Total Samples

Submitter’s Institution

NIAID NIH

Authors

Dooley KE, Warburton A, McBride AA

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-75987

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