Expression data of epithelial organoid cultures generated from intestinal mucosa of non-IBD controls and patients with ulcerative colitis

GSE75916

Homo sapiens

35 Downloadable Samples

Affymetrix Human Genome U219 Array (hgu219)

Submitter Supplied Information

Description

The transcriptional signature of mucosa of patients with ulcerative colitis (UC) in remission reveals long-lasting changes in the epithelial barrier which persist once the inflammatory response has resolved. In order to investigate if these changes are caused by primary defects in the epithelial cells, we generated in vitro epithelial organoid cultures (EpOCs) from colon samples of non-IBD controls and UC patients.

PubMed ID

27803115

Publication Title

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis.

Total Samples

Submitter’s Institution

IDIBAPS

Authors

Dotti I, Mora-Buch R, Ferrer-Picón E, Planell N, Jung P, Masamunt MC, Leal RF, Martín de Carpi J, Llach J, Ordás I, Batlle E, Panés J, Salas A

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-75916

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