Gene expression studies in IEC-6 cells induced by non-steroidal anti-inflammatory agents

GSE7584

Rattus norvegicus

14 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively as therapeutic agents, despite their well-documented gastrointestinal (GI) toxicity. Presently, the mechanisms responsible for NSAID-associated GI damage are incompletely understood. In this study, we used Microarray analysis to generate a novel hypothesis about cellular mechanisms that underlie the GI toxicity of NSAIDs. Monolayers of intestinal epithelial

PubMed ID

18281595

Publication Title

Drug-induced alterations to gene and protein expression in intestinal epithelial cell 6 cells suggest a role for calpains in the gastrointestinal toxicity of nonsteroidal anti-inflammatory agents.

Total Samples

Submitter’s Institution

Kansas State University

Authors

Raveendran NN, Silver K, Freeman LC, Narvaez D, Weng K, Ganta S, Lillich JD

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-7584

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