Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated in vitro systems are: HepaRG cells, HepG2 cells and a novel human skinpostnatal stem cell-derived model i.e. human skin-precursors-derived hepatocyte-like cells (hSKP-HPC).

23

Rodrigues RM, Govaere O, Roskams T, Vanhaecke T, Rogiers V, De Kock J