Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes

Cardiac hypertrophy is associated with growth and functional changes of cardiomyocytes,including mitochondrial alterations, but the latter are still poorly understood. Here we investigated mitochondrial function and dynamic localization in neonatal rat ventricular cardiomyocytes (NRVCs) stimulated with insulin like growth factor 1 (IGF1) or phenylephrine (PE), mimicking physiological and pathological hypertrophic responses,respectively.

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Tigchelaar W, de Jong AM, Bloks VW, van Gilst WH, de Boer RA, Silljé HH