ATFS-1 regulates a broad protective transcriptional program

We previously identified a number of genes which were differentially expressed during mitochondrial stress in an ATFS-1-dependent manner using an atfs-1 loss-of-function mutant allele . To complement the findings from our previous microarray, we compared the transcript profiles from wild-type and atfs-1(et18) gain-of-function worms (which have constitutively active ATFS-1) in the absence of mitochondrial stress.

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Lin YF, Schulz AM, Pellegrino MW, Lu Y, Shaham S, Haynes CM