Role of Histone Deacetylase 4 on cardiac expression after exercise

Physiological exercise leads to an activation of an distinct genetic program in the heart. During this process, we identified histone deacetlyase 4 (HDAC4) as an epigentic modifier, that regulates this adaptive process. To identify HDAC4 dependent genes that can are regulated after physiological stress, we investigated the cardiac gene expression in cardiomyocyte specific HDAC4 knockout animals and control animals after running exercise.

12