Toxicogenomics on mice liver of coumarins from Calophyllum brasiliense

A toxicogenomic analysis from liver of different pharmacological active coumarins (mammea A/BA+A/BB 3:1 and soulatrolide ) was performed on mice treated (20mg/kg/daily) for a whole week to evaluate if such compounds possess or could develop a hazardous profile on liver.

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Gomez-Verjan JC, Estrella-Parra EA, Gonzalez-Sanchez I, Rivero-Segura NA, Vazquez-Martinez R, Magos-Guerrero G, Mendoza-Villanueva D, Cerbón-Cervantes MA, Reyes-Chilpa R