Evaluation of murine mast cells derived exosomal RNA versus their parental cells MC/9.

Exosomes are vesicles of endocytic origin released by many types of cells into the extracellular environment. In an attempt to further examine the exosome-mediated cellular communication, we show that exosomes from a mouse mast cell line (MC/9), exosomes from primary bone marrow derived mast cells, and exosomes from a human mast cell line (HMC-1) contain RNA but not DNA.

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Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO