p53 amplifies Toll-like receptor 5 response in MCF-7 cells

Using gene expression profiling we characterize the global effect of p53 on the TLR5-mediated transcription in MCF7 cells. We found that combined activation of p53 and TLR5 pathways synergistically increases expression of over 200 genes, mostly associated with immunity and inflammation. The synergy was observed in several human cancer cells and primary lymphocytes.

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Shatz M, Shats I, Menendez D, Resnick MA