Time course expression data from Brown Norway rat livers treated with nevirapine or galactosamine or both

Nevirapine alone produces only mild hepatic hypertrophy in the rat. Single ip dose galactosamine produces transient hepatocellular apoptotic and oncotic cell death mimicking viral hepatitis with portal inflammatory infiltrate and biliary hypertrophy and hyperplasia. Damage is typically resolved within 7-10 days. However if rats are pretreated with nevirapine at specific doses for 7 days prior to the single galactosamine dose, bridging fibrosis is observed, 8 days after the single galactosamine dose is given.

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Brown HR, Castellino S, Groseclose MR, Elangbam CS, Mellon-Kusibab K, Yoon LW, Gates LD, Krull DL, Cariello NF, Arrington-Brown L, Tillman T, Fowler S, Shah V, Bailey D, Miller RT