Endothelin-Mediated Changes in Gene Expression in Isolated Purified Rat Retinal Ganglion Cells

A growing body of evidence suggests that the vasoactive peptides endothelins (ETs) and their receptors (primarily the ETB receptor) are contributors to neurodegeneration in glaucoma. However, ETs actions in retinal ganglion cells (RGCs) are not fully understood. The purpose of this study was to determine ETs effects on gene expression in primary RGCs.

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He S, Park YH, Yorio T, Krishnamoorthy RR