Negative-Pressure Induces p120-Catenin Dependent Adherens Junction Disassembly

Background: Negative-pressure wound therapy has become widely available in modern chronic wound cares. Accelerated keratinocyte (HaCaT cell) movements and decreased E-cadherin expressions induced by the applied negative pressure gradient of 125 mmHg (NP) have been reported in previous studies. However, the molecular mechanism for E-cadherin regulations under NP remains unexplored. We highlighted the signal transduction involved in NP-induced E-cadherin regulation for keratinocytes in the study.

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Huang CH, Hsu CC, Chen CP, Chow SE, Wang JS, Shyu YC, Lu MJ