Gene expression profiling in NK cells of patients infected with Leishmania mexicana

GSE69252

Homo sapiens

18 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

The aim of this study was to identify differences in the NK-cell response towards Leishmania mexicana lipophosphoglycan (LPG) between patients with localized (LCL) and diffuse (DCL) cutaneous leishmaniasis through gene expression profiling, in an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfunction in patients with DCL.

PubMed ID

27031998

Publication Title

Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana.

Total Samples

Submitter’s Institution

University of Cambridge

Authors

Fernández-Figueroa EA, Imaz-Rosshandler I, Castillo-Fernández JE, Miranda-Ortíz H, Fernández-López JC, Becker I, Rangel-Escareño C

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-69252

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