Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines

GSE69078

Homo sapiens

10 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

KMS-11 and KMS-34 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell cultures, denoted KMS-11/Cfz and KMS-34/Cfz, respectively, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.

PubMed ID

26109433

Publication Title

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.

Total Samples

Submitter’s Institution

George Washington University

Authors

Riz I, Hawley TS, Hawley RG

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-69078

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