Whole blood gene expression profiling in preclinical and clinical cattle infected with atypical bovine spongiform encephalopathy.

The molecular events at the basis of prion diseases are characterized by the involvement of several genes which are differentially regulated during the onset and the progression of the infection. Gene expression profiling studies are a powerful tool for the development of preclinical diagnostic tests. Most of the studies performed up to date utilized tissues which are not suitable for a future perspective of a rapid analysis of the infected animals and patients.

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Xerxa E, Barbisin M, Chieppa MN, Krmac H, Vallino Costassa E, Vatta P, Simmons M, Caramelli M, Casalone C, Corona C, Legname G