Targets of Pax3 and Zic1 in neural crest and cranial placode progenitors

The transcription factors Pax3 and Zic1 are among the earliest genes activated at the neural plate border. Pax3 and Zic1 in combination promote neural crest fate, while Zic1 alone regulate cranial placode progenitor formation. We used microarrays to identify the global repertoire of genes activated by these facors individually or in combination to gain insights into the molecular mechanisms underlying cell fate decision at the neural plate border.

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Bae CJ, Park BY, Lee YH, Tobias JW, Hong CS, Saint-Jeannet JP