Effects of ischemia reperfusion injury or nephrectomy on mouse lung

GSE6730

Mus musculus

20 Downloadable Samples

Affymetrix Mouse Expression 430A Array (moe430a)

Submitter Supplied Information

Description

Experiments in rodents have shown that kidney ischemia/reperfusion injury (IRI) facilitates lung injury and inflammation. To identify potential ischemia-specific lung molecular pathways involved, we conducted global gene expression profiling of lung 6 or 36 hours following 1) bilateral kidney IRI, 2) bilateral nephrectomy (BNx), and 3) sham laparotomy in C57BL/6J mice. Total RNA from whole lung was isolated and hybridized to 430MOEA (22,626 genes) GeneChips (n=3/group).

PubMed ID

17327501

Publication Title

Ischemic acute kidney injury induces a distant organ functional and genomic response distinguishable from bilateral nephrectomy.

Total Samples

Submitter’s Institution

JHU

Authors

Hassoun HT, Grigoryev DN, Lie ML, Liu M, Cheadle C, Tuder RM, Rabb H

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-6730

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