Eomes+ natural Th1 (nTh1) T cells share functional features with classical Th1 (cTh1) cells.

Identification of intrathymic Eomes+ natural Th1 cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. To more deeply characterize this type of innate T cells, we compared the gene expression profile between nTh1 cells generated in CIITAtg mice and classic Th1 cells differentiated from naive CD4 T cells in Th1-polarizing condition.

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Kang BH, Park HJ, Yum HI, Park SP, Park JK, Kang EH, Lee JI, Lee EB, Park CG, Jung KC, Park SH