Identification of genes involved with P. aeruginosa biofilm antibiotic resistance by microarray analysis

Microarray analysis was used to identify changes in the level of transcription of genes in P. aeruginosa drip flow biofilms in response to ciprofloxacin and tobramycin exposure. This data was evaluated and used to select strains that carry transposon mutations in genes that might play a role in antibiotic tolerance of biofilms. The strains were evaluated for defects in biofilm tolerance.

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Stewart PS, Franklin MJ, Williamson KS, Folsom JP, Boegli L, James GA