Adiponectin-cre FTO flox/flox and FTO flox/flox mouse white fat tissues

Single nucleotide polymorphisms in intron 1 of the fat mass and obesity-associated (FTO) gene were found to be associated with an increased risk of adult obesity. Enhanced FTO expression in mice leads to hyperphagia, increased fat mass, and higher body weight. Neuronal-specific FTOdeleted mice have an identical lean body weight phenotype to global FTO-deleted mice. The physiological role of adipose FTO in the homeostasis of energy regulation remains to be elucidated.

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Wang CY, Shie SS, Wen MS, Hung KC, Hsieh IC, Yeh TS, Wu D