Expression data from study on IL33 signaling in Dusp5 deficient eosinophils

Dusp5 regulates ERK phosporylation following IL-33 receptor ligation in cultured eosinophils. Dusp5 deficient eosinophils show increased ERK phosphorylation, and as a result are less apoptotic. Since ERK stimulation results in downstream activation of transcription factors, we are utilizing a microarray approach to find alterations in gene expression to uncover potential mechanisms for increased cell survival.

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Holmes DA, Yeh JH, Yan D, Xu M, Chan AC