Genome-wide expression profiling after Valproic acid treatment in Saccharomyces cerevisiae

GSE62400

Saccharomyces cerevisiae

4 Downloadable Samples

Affymetrix Yeast Genome 2.0 Array (yeast2)

Submitter Supplied Information

Description

Valproic acid (VA) is a small-chain branched fatty acid, widely used as anticonvulsant, and mood stabilizer to treat psychiatric illness. Valproic acid is also known to inhibit the histone deacetylases (HDACs), which makes it as a potent antitumor agent in alone or in combination with other cytotoxic drugs. Beside its conventional activities, valproic acid reported to have much broader, complicated effects and affect many complex physiological processes. However the molecular mechanisms of valproic acid are unclear.

PubMed ID

27734932

Publication Title

Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model.

Total Samples

Submitter’s Institution

Indian Institute of Science Education & Research

Authors

Golla U, Joseph D, Tomar RS

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-62400

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