Genome-wide expression profiling after Allyl Alcohol treatment in Saccharomyces cerevisiae

GSE62399

Saccharomyces cerevisiae

4 Downloadable Samples

Affymetrix Yeast Genome 2.0 Array (yeast2)

Submitter Supplied Information

Description

Allyl alcohol is a highly toxic industrial chemical used as a synthetic substrate, and as an herbicide in agriculture. It is evident that Allyl alcohol is metabolized by alcohol dehydrogenases (ADH) to the highly toxic Acrolein. Acrolein is a simple unsaturated aldehyde, ubiquitous environmental pollutant, endogenous metabolite and major constituent of cigarette smoke. Acrolein is highly electrophilic in nature and has strong reactivity towards nucleophiles present in cell such as amino acids, proteins and DNA.

PubMed ID

25919230

Publication Title

Molecular cytotoxicity mechanisms of allyl alcohol (acrolein) in budding yeast.

Total Samples

Submitter’s Institution

Indian Institute of Science Education & Research

Authors

Golla U, Bandi G, Tomar RS

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-62399

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