Expression data from rhesus macaque blood CD8+ T cells

Immunization of macaques with simian immunodeficiency virus with deletions in nef (SIVnef) has been shown to elicit protective immunity to infection by pathogenic SIV, yet our understanding of the mechanisms that orchestrate protection and prevent pathogenesis remains limited. In the study, we utilize whole-genome transcriptional profiling to reveal molecular signatures of protective immunity in circulating CD8+ T cells of rhesus macaques vaccinated with SIVmac239nef and challenged with pathogenic SIVmac251.

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