Expression data from immortalized and transformed WT and HGPS cell lines

Primary skin fibroblasts from HGPS patients and an age-matched control wild-type individuals were challenged in a standard transformation assay by retroviral introduction of TERT (T), V12-HRAS (R) and SV40 large and small T antigens (S). TERT-Immortalized cell lines from the same sources were also generated.

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Fernandez P, Scaffidi P, Markert E, Lee JH, Rane S, Misteli T