Expression data of rat insulinoma cells induced with ER stress +/- IRE1 inhibitor treatment

The Akita mutation (C96Y) in the insulin gene results in early onset diabetes in both humans and mice. Expression of the mutant proinsulin (C96Y) causes endoplasmic reticulum (ER) stress in pancreatic -cells and consequently the cell activates the unfolded protein response (UPR). Since the proinsulin is terminally misfolded however, the ER stress is irremediable and chronic activation of the UPR eventually activates apoptosis in the cell population.

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Zhang L, Nosak C, Sollazzo P, Odisho T, Volchuk A