Amniotic fluid RNA gene expression profiling provides insights into the phenotype of Turner syndrome

Background: Turner syndrome, a common sex chromosome aneuploidy, has characteristics and malformations associated with the phenotype. Fetal amniotic fluid is a complex biological material that could contribute to the understanding Turner syndrome pathogenesis. Global gene expression analysis of Turner syndrome fetal amniotic fluid supernatant was utilized to identify organ systems and specific genes that may play a role in the pathophysiologic changes that are seen in individuals with Turner syndrome.

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Massingham LJ, Johnson KL, Scholl TM, Slonim DK, Wick HC, Bianchi DW