Identification of genes associated with breast cancer micrometastatic disease in bone marrow using a Patient Derived Xenograft mouse model

In this study, using a Patient Derived Xenograft (PDX) system established by transplanting primary tumors from pre-metastatic breast cancer patients we demonstrate that development of distant organ metastases correlates with the presence of Bone Marrow Disseminated Tumor Cells (BM DTCs) in the PDX mice. Comparative gene expression analysis of bone marrow (BM) from tumor bearing PDX mice which developed metastatic disease was carried out with BM from non-tumor bearing controls.

11

Pillai SG, Li S, Siddappa CM, Ellis MJ, Watson MA, Aft R