Expression data for Control and SMRT-Depleted MCF-7 Cells

Estrogens are an important regulator of breast cancer disease progression, and they function by binding the estrogen receptor- (ER) to regulate changes in gene expression. ER is able to both activate and inhibit gene transcription in a gene-specific manner and do so by binding target DNA sequences and recruiting coactivators and corepressors which can modulate the chromatin environment. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) is known to act as coactivator and corepressor of ER in a gene-specific manner.

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Blackmore JK, Karmakar S, Gu G, Chaubal V, Wang L, Li W, Smith CL