Impact of high-phosphate diet on aortic gene expression

Uremic media calcification is not only driven by systemic factors such as hyperphosphatemia, but also crticially dependent on vascular smooth muscle cells per se. We hypothesized that the different developmental origins of vscular smooth muscle cells might lead to a heterogeneous susceptibility to develop media calcification.

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Kirsch AH, Kirsch A, Artinger K, Schabhüttl C, Goessler W, Klymiuk I, Gülly C, Fritz GA, Frank S, Wimmer R, Brodmann M, Anders HJ, Pramstaller PP, Rosenkranz AR, Eller K, Eller P