Patterns of gene expression associated with recovery and injury in heat-stressed rats

Background: The in vivo gene response associated with hyperthermia and subsequent return to homeostasis or development of heat illness is poorly understood. Early activation of gene networks in the heat stress response is likely to lead to the systemic inflammation, multi-organ functional impairment, and other pathophysiological states characteristic of heat illness. Here, we perform an unbiased global characterization of the multi-organ gene response using an in vivo model of heat stress in the conscious rat.

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Stallings JD, Ippolito DL, Rakesh V, Baer CE, Dennis WE, Helwig BG, Jackson DA, Leon LR, Lewis JA, Reifman J