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Accession IconGSE56416

Intrathymic origins of T-ALL

Organism Icon Mus musculus
Sample Icon 26 Downloadable Samples
Technology Badge IconIllumina MouseWG-6 v2.0 R2 expression beadchip

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Description
Leukemia cells are considered developmentally 'frozen', and their phenotype is thought to reflect their stage of origin. To gain insights into the cell population from which T-ALL arises, we compared by global gene expression profiling T-ALL samples (n = 10) to different stages of T cell development, following the order from early thymic progenitor (ETP), to triple negative (TN) TN2, to TN3, to TN4, to immature single positive (ISP), to double positive (DP) thymocytes.
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26
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