Inflammation-induced chemokine expression in uveal melanoma cell lines stimulates monocyte chemotaxis

Purpose: Uveal melanoma (UM) is the most common primary intraocular tumor in adults and the presence of infiltrating leucocytes is associated with a poor prognosis. Little is known how infiltrating leucocytes influence the tumor cells. The purpose of this study was to investigate the effect of activated T cells on the expression of chemotactic cytokines in UM cells. Furthermore, we examined the ability of stimulated UM cells to attract monocytes.

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Jehs T, Faber C, Juel HB, Bronkhorst IH, Jager MJ, Nissen MH