Role of DNA Topoisomerase IIbeta in Gene Expression

Mice lacking topoisomerase II (Top II) are known to exhibit a perinatal death phenotype. In the current study, transcription profiles of the brains of wild type and top2 knockout mouse embryos were generated. Surprisingly, only a small number (1-4%) of genes were affected in top2 knockout embryos. However, the expression of nearly 30% of developmentally regulated genes was either up- or down-regulated.

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Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF