Expression data of articular and growth plate cartilage zones in 10-day-old rat proximal tibial epiphysis

Articular and growth plate cartilage have comparable structures consisting of three distinct layers of chondrocytes, suggesting similar differentiation programs and therefore similar gene expression profiles. To address this hypothesis and to explore transcriptional changes that occur during the onset of articular and growth plate cartilage divergence, we used microdissection of 10-day-old rat proximal tibial epiphyses, microarray analysis, and bioinformatics to compare gene expression profiles in individual layers of articular and growth plate cartilage.

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Chau M, Lui JC, Landman EB, Späth SS, Vortkamp A, Baron J, Nilsson O