Expression data from Sin3Bp+/-KRaspG12D and Sin3Bp-/-KRaspG12D pancreata and from cultured primary pancreatic duct epithelial cells (PDEC) of the same genotype.

Pancreatic ductal adenocarcinoma (PDAC) is strikingly resistant to conventional approaches. In this study, we report that the histone deacetylase associated SIN3B protein is required for activated KRAS-induced senescence in vivo using a mouse model of pancreatic cancer.

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Rielland M, Cantor DJ, Graveline R, Hajdu C, Mara L, Diaz Bde D, Miller G, David G