Differential regulation patterns of anti-CD20 mAbs in MCL

GSE54169

Homo sapiens

74 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

We investigated the differential regulation patterns of type I anti-CD20 monoclonal antibody (mAb) rituximab and type II obinutuzumab on a transcriptional level. Using a panel of MCL cell lines, we determined the effects of obinutuzumab and rituximab as monotherapies as well as in combination on cell viability and proliferation.

PubMed ID

25292485

Publication Title

Differential regulation patterns of the anti-CD20 antibodies obinutuzumab and rituximab in mantle cell lymphoma.

Total Samples

Submitter’s Institution

Roche Pharma

Authors

Heinrich DA, Weinkauf M, Hutter G, Zimmermann Y, Jurinovic V, Hiddemann W, Dreyling M

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-54169

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