Gene expression profile of human epidermal keratinocytes in response to IFNgamma, IL-4, IL-6, IL-17A and IL-22

GSE53751

Homo sapiens

12 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

To understand the role of epidermal keratinocytes in immunopathology of skin diseases with predominant T helper (Th) cell responses, we measured the genome-wide transcriptional profile of human keratinocytes in response to IFNgamma, IL-4, IL-17A or IL-22, major cytokines produced by Th1, Th2, Th17 or Th22 cells, respectively.

PubMed ID

25168428

Publication Title

Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors.

Total Samples

Submitter’s Institution

Seoul National University

Authors

Jin SH, Choi D, Chun YJ, Noh M

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-53751

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