Gene expression analysis in liver collected from mice administered non-toxic, toxic, or severely toxic LNA sequences

GSE53230

Mus musculus

56 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Development of LNA gapmers, antisense oligonucleotides used for efficient inhibition of target RNA expression, is limited by non-target mediated hepatotoxicity issues. In the present study, we investigated hepatic transcription profiles of mice receiving non-toxic and toxic LNA gapmers after a single and repeat administration.

PubMed ID

24336348

Publication Title

Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.

Total Samples

Submitter’s Institution

Pfizer

Authors

Kakiuchi-Kiyota S, Koza-Taylor PH, Mantena SR, Nelms LF, Enayetallah AE, Hollingshead BD, Burdick AD, Reed LA, Warneke JA, Whiteley LO, Ryan AM, Mathialagan N

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-53230

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